Studies on 8??aminoquinoline 1??oxide antimalarial agents

JL Johnson, DF Worth, NL Colbry…

文献索引：Johnson; Worth; Colbry; Werbel Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 4 p. 1093 - 1096

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被引用次数: 2

摘要

Abstract The synthesis of N-oxides of 8-aminoquinolines related to primaquine has been explored in an effort to obtain a less toxic, curative, antimalarial drug. Several side chain N- oxide analogs (2b, 3b) were prepared as well as the ring N-oxide of primaquine with both amines trifluoroacetylated (13). All attempts to deblock this material failed. Trifluoroacetylation of primaquine also yielded the novel acyl analog 12 which had ...