Journal of heterocyclic chemistry

Furopyridines. VI. Preparation and reactions of 2??and 3??substituted furo [2, 3??b] pyridines

H Morita, S Shiotani

文献索引：Morita, Hiroyuki; Shiotani,Shunsaku Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 1465 - 1469

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被引用次数: 17

摘要

Abstract This paper describes the synthesis and chemical properties of some 2-and 3- substituted furo [2, 3-b] pyridines. Reaction of ethyl 2-chloronicotinate 1 with sodium ethoxycarbonylmethoxide or 1-ethoxycarbonyl-1-ethoxide gave β-keto ester 2 or ketone 5, respectively. Ketonic hydrolysis of 2 afforded ketone 3, from which furo [2, 3-b] pyridine 4 was obtained by the method of Sliwa. While, 2-methyl derivative 7 was prepared from 5 by ...