Organic letters

One-Step Synthesis of α-Chloro Acetophenones from Acid Chlorides and Aryl Precursors

J Rosen, D Steinhuebel, M Palucki, I Davies

文献索引：Rosen, Jonathan; Steinhuebel, Dietrich; Palucki, Michael; Davies, Ian Organic Letters, 2007 , vol. 9, # 4 p. 667 - 669

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被引用次数: 8

摘要

A direct and efficient method was developed for the preparation of a variety of substituted acetophenone derivatives from readily available arene precursors and acid chlorides. This method has significant generality and affords access to substitution patterns on aryl rings not directly achievable by Friedel-Crafts chemistry.