Tetrahedron

Double annulations of dihydroxy-and diacetoxy-dialkynylbenzenes. An efficient construction of benzodifurans

Z Liang, S Ma, J Yu, R Xu

文献索引：Liang, Zhiqiang; Ma, Shengming; Yu, Jihong; Xu, Ruren Tetrahedron, 2007 , vol. 63, # 52 p. 12877 - 12882

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被引用次数: 19

摘要

An efficient synthetic route to construct disubstituted benzodifurans from dihydroxy-or diacetoxy-dialkynylbenzenes utilizing Cs2CO3 or Pd (OAc) 2/Cs2CO3 promoted double annulations is described. The scope for the reaction in the presence of a catalytic amount of Pd (OAc) 2 is more general. In addition, it was observed that NaOH-promoted reaction of diacetoxy-dialkynylbenzenes may directly afford in THF/MeOH/H2O at 80° C ...