Design, synthesis, and structure–activity relationship studies of new phenolic DNA gyrase inhibitors

T Lübbers, P Angehrn, H Gmünder, S Herzig

文献索引：Luebbers, Thomas; Angehrn, Peter; Gmuender, Hans; Herzig, Silvia Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4708 - 4714

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被引用次数: 63

摘要

Starting from a biased needle screening hit 3a, we report herein the design and synthesis of a series of novel 2, 3-dihydroisoindol-1-ones structurally related to cyclothialidine 2 with DNA gyrase inhibitory activity. In this series, some compounds exhibited promising antibacterial activity against Gram-positive bacterial strains.