Polymeric conjugates of 9-[2-(phosphonomethoxy) ethyl] purine with potential antiviral and cytostatic activity

M Pechar, A Braunová, V Šubr…

文献索引：Pechar, Michal; Braunova, Alena; Subr, Vladimir; Ulbrich, Karel; Holy, Antonin Collection of Czechoslovak Chemical Communications, 2006 , vol. 71, # 8 p. 1211 - 1220

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被引用次数: 3

摘要

Abstract Syntheses and characterization of polymer conjugates of 9-[2-(phosphonomethoxy) ethyl](PME) derivatives of adenine (PMEA), 2, 6-diaminopurine (PMEDAP) and guanine (PMEG) are described. The phosphonate group of these acyclic nucleotide analogues was activated by reaction with triphenylphosphine and di (2-pyridyl) disulfide (TPP-PDS). The activated phosphonate reacted with a random copolymer containing N-(2-hydroxypropyl) ...