Synthesis of acyclic nucleotide analogues derived from 6-(sec-or tert-alkyl) purines via coupling of 6-chloropurine derivatives with organocuprates

H Dvořáková, D Dvořák, A Holý

文献索引：Dvorakova, Hana; Dvorak, Dalimil; Holy, Antonin Collection of Czechoslovak Chemical Communications, 1998 , vol. 63, # 12 p. 2065 - 2074

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被引用次数: 12

摘要

Abstract Coupling of 9-[2-(diisopropyloxyphosphonylmethoxy) ethyl]-6-chloropurine (23)(and (R)-9-[2-(diisopropyloxyphosphonylmethoxy) propyl]-6-chloropurine (24), respectively) with organocuprates derived from Grignard reagents afforded after deprotection 6-(sec-or tert-alkyl) substituted phosphonates 31-36. As a model a series of 6- (sec-or tert-alkyl) purines 2-12 was also prepared.