Synthesis of aminopropyl phosphonate nucleosides with purine and pyrimidine bases

D Zhou, IM Lagoja, A Van Aerschot…

文献索引：Zhou, Ding; Lagoja, Irene M.; Van Aerschot, Arthur; Herdewijn, Piet Collection of Czechoslovak Chemical Communications, 2006 , vol. 71, # 1 p. 15 - 34

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被引用次数: 18

摘要

Abstract The synthesis and antiviral evaluation of new acyclic phosphonate nucleosides related to HPMPC (Cidofovir) has been described. These aminopropyl phosphonate nucleosides 1-3 have an amino function within either the acyclic chain (series 2 and 3) or as substituent (series 1). Both purine and pyrimidine nucleotide analogues have been synthesized. In contrast to HPMPC the oxygen analogue of 2c, only a weak antiherpes ...