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Bioorganic & medicinal chemistry

Novel non-classical C9-methyl-5-substituted-2, 4-diaminopyrrolo [2, 3-d] pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents

A Gangjee, J Yang, SF Queener

文献索引:Gangjee, Aleem; Yang, Jie; Queener, Sherry F. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8341 - 8351

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被引用次数: 18

摘要

Six novel C9-methyl-5-substituted-2, 4-diaminopyrrolo [2, 3-d] pyrimidines 18–23 were synthesized as potential inhibitors of dihydrofolate reductase (DHFR) and as anti- opportunistic agents. These compounds represent the only examples of 9-methyl substitution in the carbon–carbon bridge of 2, 4-diaminopyrrolo [2, 3-d] pyrimidines. The analogs 18–23 were synthesized in a concise eight-step procedure starting from the ...