Synthesis and biological properties of amino acid amide ligand-based pyridinioalkanoyl thioesters as anti-HIV agents

…, V Basrur, PEA Roberts, JA Mikovits, JK Inman…

文献索引：Song, Yongsheng; Goel, Atul; Basrur, Venkatesha; Roberts, Paula E.A; Mikovits, Judy A; Inman, John K; Turpin, Jim A; Rice, William G; Appella, Ettore Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 5 p. 1263 - 1273

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被引用次数: 33

摘要

Hyper-mutable retroviruses such as HIV can become rapidly resistant to drugs used to treat infection. Strategies for coping with drug-resistant strains of virus include combination therapies, using viral protease and reverse transcriptase inhibitors. Another approach is the development of antiviral agents that attack mutationally nonpermissive targets that have functions essential for viral replication. Thus, the highly conserved nucleocapsid protein, ...