One??Pot Three??Component Heteroannulation of β??Oxo Dithioesters, Amines and Hydroxylamine: Regioselective, Facile and Straightforward Entry to 5??Substituted 3?? …
S Samai, T Chanda, H Ila…
文献索引：Samai, Subhasis; Chanda, Tanmoy; Ila, Hiriyakkanavar; Singh, Maya Shankar European Journal of Organic Chemistry, 2013 , # 19 p. 4026 - 4031
Abstract An efficient and highly regioselective one-pot three-component synthesis of previously inaccessible and synthetically demanding 3-(cycloalkyl/alkyl/arylamino)-5- aryl/alkylisoxazoles has been achieved by the cyclocondensation of β-oxo dithioesters, amines and hydroxylamine in ethanol at reflux. This transformation proceeds via an in situ generated β-oxothioamide by the reaction of the β-oxo dithioester and amine, which ...
