Total chemical synthesis and antitumor evaluation of 4-demethoxy-10, 10-dimethyldaunomycin

J Alexander, I Khanna, D Lednicer…

文献索引：Alexander, Jose; Khanna, Ish; Lednicer, Daniel; Mitscher, Lester A.; Veysoglu, Tarik; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1343 - 1347

全文：HTML全文

被引用次数: 5

摘要

Synthetic studies on anthracycline antitumor antibiotics such as daunomycin (1) and doxorubicin (2) have been pursued intensively. lI2 Present interest is turning increasingly to total synthesis of unnatural analogues inaccessible from fermentation-derived substrates in the hope of producing drugs with significantly altered biological properties. 14 In this context we report here our experiences in the total synthesis and antitumor evaluation of 4- ...