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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

On the syntheses of thiophene analogs of practolol and “reversed” practolol

…, S Conde, C Corral, J Lissavetzky

文献索引：Casarrubio; Conde; Corral; Lissavetzky Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 6 p. 1557 - 1560

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被引用次数: 3

摘要

Abstract The synthesis of the thiophene analogs of the cardio-selective β-adrenergic blocking agents Practolol and “reversed” Practolol has been attempted starting from 2-acetyl- 5-bromothiophene. Although this synthesis worked for the second compound it was not possible to obtain the first one. From this and other results of this paper it can be deduced that the thiophene analog of Practolol must be an unstable compound.

1-(5-(2-methyl-1,3-dioxolan-2-yl)-2-thienyloxy)-2,3-O-isopropylidenepropane结构式

1-(5-(2-methyl-...

~75%

1-[5-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]thiophen-2-yl]ethanone结构式

1-[5-[(2,2-dime...

2-乙酰基-5-溴噻吩结构式

2-乙酰基-5-溴噻吩

~%

1-[5-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]thiophen-2-yl]ethanone结构式

1-[5-[(2,2-dime...

2-(5-bromothiophen-2-yl)-2-methyl-1,3-dioxolane结构式

2-(5-bromothiop...

~%

1-[5-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]thiophen-2-yl]ethanone结构式

1-[5-[(2,2-dime...

丙酮缩甘油结构式

丙酮缩甘油

~%

1-[5-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]thiophen-2-yl]ethanone结构式

1-[5-[(2,2-dime...

1-(5-methylcarbamoyl-2-thienyloxy)-2,3-O-isopropylidenepropane结构式

1-(5-methylcarb...

~83%

5-(2,3-dihydroxypropoxy)-N-methylthiophene-2-carboxamide结构式

5-(2,3-dihydrox...

2-乙酰基-5-溴噻吩结构式

2-乙酰基-5-溴噻吩

~%

5-(2,3-dihydroxypropoxy)-N-methylthiophene-2-carboxamide结构式

5-(2,3-dihydrox...

2-(5-bromothiophen-2-yl)-2-methyl-1,3-dioxolane结构式

2-(5-bromothiop...

~%

5-(2,3-dihydroxypropoxy)-N-methylthiophene-2-carboxamide结构式

5-(2,3-dihydrox...

1-[5-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]thiophen-2-yl]ethanone结构式

1-[5-[(2,2-dime...

~%

5-(2,3-dihydroxypropoxy)-N-methylthiophene-2-carboxamide结构式

5-(2,3-dihydrox...

1-(5-(2-methyl-1,3-dioxolan-2-yl)-2-thienyloxy)-2,3-O-isopropylidenepropane结构式

1-(5-(2-methyl-...

~%

5-(2,3-dihydroxypropoxy)-N-methylthiophene-2-carboxamide结构式

5-(2,3-dihydrox...

(Z)-1-(5-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)thiophen-2-yl)ethan-1-one oxime结构式

(Z)-1-(5-((2,2-...

~%

5-(2,3-dihydroxypropoxy)-N-methylthiophene-2-carboxamide结构式

5-(2,3-dihydrox...

2-乙酰基-5-溴噻吩结构式

2-乙酰基-5-溴噻吩

乙二醇结构式

~94%

2-(5-bromothiophen-2-yl)-2-methyl-1,3-dioxolane结构式

2-(5-bromothiop...

(Z)-1-(5-(oxiran-2-ylmethoxy)thiophen-2-yl)ethan-1-one oxime结构式

(Z)-1-(5-(oxira...

~72%

N-methyl-5-(oxiran-2-ylmethoxy)thiophene-2-carboxamide结构式

N-methyl-5-(oxi...

2-乙酰基-5-溴噻吩结构式

2-乙酰基-5-溴噻吩

~%

N-methyl-5-(oxiran-2-ylmethoxy)thiophene-2-carboxamide结构式

N-methyl-5-(oxi...

2-(5-bromothiophen-2-yl)-2-methyl-1,3-dioxolane结构式

2-(5-bromothiop...

~%

N-methyl-5-(oxiran-2-ylmethoxy)thiophene-2-carboxamide结构式

N-methyl-5-(oxi...

1-(5-(2-methyl-1,3-dioxolan-2-yl)-2-thienyloxy)-2,3-O-isopropylidenepropane结构式

1-(5-(2-methyl-...

~%

N-methyl-5-(oxiran-2-ylmethoxy)thiophene-2-carboxamide结构式

N-methyl-5-(oxi...

1-[5-(oxiran-2-ylmethoxy)thiophen-2-yl]ethanone结构式

1-[5-(oxiran-2-...

~%

N-methyl-5-(oxiran-2-ylmethoxy)thiophene-2-carboxamide结构式

N-methyl-5-(oxi...

1-[5-(2,3-dihydroxypropoxy)thiophen-2-yl]ethanone结构式

1-[5-(2,3-dihyd...

~%

N-methyl-5-(oxiran-2-ylmethoxy)thiophene-2-carboxamide结构式

N-methyl-5-(oxi...

1-[5-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]thiophen-2-yl]ethanone结构式

1-[5-[(2,2-dime...

~%

N-methyl-5-(oxiran-2-ylmethoxy)thiophene-2-carboxamide结构式

N-methyl-5-(oxi...

(Z)-1-(5-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)thiophen-2-yl)ethan-1-one oxime结构式

(Z)-1-(5-((2,2-...

~%

N-methyl-5-(oxiran-2-ylmethoxy)thiophene-2-carboxamide结构式

N-methyl-5-(oxi...

5-(2,3-dihydroxypropoxy)-N-methylthiophene-2-carboxamide结构式

5-(2,3-dihydrox...

~%

N-methyl-5-(oxiran-2-ylmethoxy)thiophene-2-carboxamide结构式

N-methyl-5-(oxi...

1-(5-methylcarbamoyl-2-thienyloxy)-2,3-O-isopropylidenepropane结构式

1-(5-methylcarb...

~%

N-methyl-5-(oxiran-2-ylmethoxy)thiophene-2-carboxamide结构式

N-methyl-5-(oxi...

1-(5-(2-methyl-1,3-dioxolan-2-yl)-2-thienyloxy)-2,3-O-isopropylidenepropane结构式

1-(5-(2-methyl-...

~92%

1-[5-(2,3-dihydroxypropoxy)thiophen-2-yl]ethanone结构式

1-[5-(2,3-dihyd...

2-乙酰基-5-溴噻吩结构式

2-乙酰基-5-溴噻吩

~%

1-[5-(2,3-dihydroxypropoxy)thiophen-2-yl]ethanone结构式

1-[5-(2,3-dihyd...

2-(5-bromothiophen-2-yl)-2-methyl-1,3-dioxolane结构式

2-(5-bromothiop...

~%

1-[5-(2,3-dihydroxypropoxy)thiophen-2-yl]ethanone结构式

1-[5-(2,3-dihyd...

2-乙酰基-5-溴噻吩结构式

2-乙酰基-5-溴噻吩

~%

1-[5-(oxiran-2-ylmethoxy)thiophen-2-yl]ethanone结构式

1-[5-(oxiran-2-...

1-[5-(2,3-dihydroxypropoxy)thiophen-2-yl]ethanone结构式

1-[5-(2,3-dihyd...

~%

1-[5-(oxiran-2-ylmethoxy)thiophen-2-yl]ethanone结构式

1-[5-(oxiran-2-...

2-(5-bromothiophen-2-yl)-2-methyl-1,3-dioxolane结构式

2-(5-bromothiop...

~%

1-[5-(oxiran-2-ylmethoxy)thiophen-2-yl]ethanone结构式

1-[5-(oxiran-2-...

1-(5-(2-methyl-1,3-dioxolan-2-yl)-2-thienyloxy)-2,3-O-isopropylidenepropane结构式

1-(5-(2-methyl-...

~%

1-[5-(oxiran-2-ylmethoxy)thiophen-2-yl]ethanone结构式

1-[5-(oxiran-2-...

1-[5-(oxiran-2-ylmethoxy)thiophen-2-yl]ethanone结构式

1-[5-(oxiran-2-...

~36%

(Z)-1-(5-(oxiran-2-ylmethoxy)thiophen-2-yl)ethan-1-one oxime结构式

(Z)-1-(5-(oxira...

N-[1-[5-(oxiran-2-ylmethoxy)thiophen-2-yl]ethylidene]hydroxylamine结构式

N-[1-[5-(oxiran...

2-乙酰基-5-溴噻吩结构式

2-乙酰基-5-溴噻吩

~%

N-[1-[5-(oxiran-2-ylmethoxy)thiophen-2-yl]ethylidene]hydroxylamine结构式

N-[1-[5-(oxiran...

2-(5-bromothiophen-2-yl)-2-methyl-1,3-dioxolane结构式

2-(5-bromothiop...

~%

N-[1-[5-(oxiran-2-ylmethoxy)thiophen-2-yl]ethylidene]hydroxylamine结构式

N-[1-[5-(oxiran...

1-[5-(2,3-dihydroxypropoxy)thiophen-2-yl]ethanone结构式

1-[5-(2,3-dihyd...

~%

N-[1-[5-(oxiran-2-ylmethoxy)thiophen-2-yl]ethylidene]hydroxylamine结构式

N-[1-[5-(oxiran...

1-(5-(2-methyl-1,3-dioxolan-2-yl)-2-thienyloxy)-2,3-O-isopropylidenepropane结构式

1-(5-(2-methyl-...

~%

N-[1-[5-(oxiran-2-ylmethoxy)thiophen-2-yl]ethylidene]hydroxylamine结构式

N-[1-[5-(oxiran...