Chemistry of thienopyridines. XVII. Direct halogenation of thieno [2, 3??b] pyridine

LH Klemm, RE Merrill, FHW Lee…

文献索引：Klemm,L.H. et al. Journal of Heterocyclic Chemistry, 1974 , vol. 11, p. 205 - 209

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被引用次数: 22

摘要

Abstract Thieno [2, 3-b] pyridine (Ia) was converted into its 3-chloro, 3-bromo, and 3-iodo derivatives by means of elemental halogen, silver sulfate, and sulfuric acid. Bromine in a buffered chloroform solution of la also gave the 3-bromo compound (57% yield). Chlorine plus a refluxing mixture of Ia, chloroform, and water produced both the 3-chloro and the 2, 3- dichloro derivatives. Various transformation products of these halothienopyridines ( ...