Tetrahedron letters

Nosylaziridines: Activated aziridine electrophiles

PE Maligres, MM See, D Askin, PJ Reider

文献索引：Maligres, Peter E.; See, Marjorie M.; Askin, David; Reider, Paul J. Tetrahedron Letters, 1997 , vol. 38, # 30 p. 5253 - 5256

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被引用次数: 132

摘要

Nosylaziridines are highly reactive electrophiles towards a variety of nucleophiles yielding the corresponding Sn2 adducts without competing attack on the nosyl functionality (SnAr). The resulting primary nosylamide adducts can be readily cleaved under mild conditions to provide the primary amines.