Highly Regioselective Alkylation at the More-Hindered α-Site of Unsymmetrical Ketones by the Combined Use of Aluminum Tris (2, 6-diphenylphenoxide) and Lithium …
S Saito, M Ito, H Yamamoto
文献索引：Saito; Ito; Yamamoto Journal of the American Chemical Society, 1997 , vol. 119, # 3 p. 611 - 612
An unsymmetrical dialkyl ketone can form two regioisomeric enolates upon deprotonation. 1 To exploit the synthetic potential of enolate ions, the regioselectivity of their formation must be controlled. By adjusting the conditions under which an enolate mixture is formed from a ketone, it is possible to establish either kinetic or thermodynamic control. Ideal conditions for kinetic control of the formation of less-substituted enolate are those in which deprotonation ...
