Aromatic ethers of 1-aryl 2-(1H-azolyl) ethanol: study of antifungal activity

…, C Tournaire, M Payard, MD Linas, JP Seguela

文献索引：Wahbi, Y.; Caujolle, R.; Tournaire, C.; Payard, M.; Linas, M. D.; Seguela, J. P. European Journal of Medicinal Chemistry, 1995 , vol. 30, # 12 p. 955 - 962

全文：HTML全文

被引用次数: 36

摘要

Aromatic ethers related to antifungal azole miconazole were synthesized and tested against various strains of Candida. We found that activity is related to the nature of the aromatic ring and the position of substituents on this ring. Activity is more strongly dependent on the substituent in the 2 position of the ethyl chain than on the aromatic group linked through the oxygen. Triazoles were always less potent than the corresponding imidazole analogues.