Pharmacophore Modeling of Substituted 1, 2, 4-Trioxanes for Quantitative Prediction of their Antimalarial Activity†

…, S Chakroborty, K Srivastava, SK Puri…

文献索引：Singh, Chandan; Verma, Ved Prakash; Naikade, Niraj Krishna; Singh, Ajit Shankar; Hassam, Mohammad; Puri, Sunil K. Journal of Medicinal Chemistry, 2008 , vol. 51, # 23 p. 7581 - 7592

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被引用次数: 9

摘要

A pharmacophore model has been developed for determining the essential structural requirements for antimalarial activity from the eight series of substituted 1, 2, 4-trioxanes. The best pharmacophore model possessing two aliphatic hydrophobic, one aromatic