Organic & biomolecular chemistry

Proline sulphonamide-catalysed Yamada–Otani condensation: reaction development, substrate scope and scaffold reactivity

H Yang, S Banerjee, RG Carter

文献索引：Yang, Hua; Banerjee, Somdev; Carter, Rich G. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 25 p. 4851 - 4863

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被引用次数: 8

摘要

The development of a proline sulphonamide-catalysed method for enantioselective and diastereoselective construction of functionalized cyclohexenones is described. Impact of catalyst structure as well as solvent effects and additives are explored. A significant substrate scope is demonstrated by variation of both the aldehyde and the enone components. Diastereoselective derivatization of the cyclohexenone scaffold illustrates its ...