Synthesis and biological properties of actinomycin D chromophoric analogs substituted at the 7-carbon with aziridine and aminopropoxy functions

RK Sehgal, B Almassian, DP Rosenbaum…

文献索引：Sehgal, Raj K.; Almassian, Bijan; Rosenbaum, David P.; Zadrozny, Ruth; Sengupta, Sisir K. Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1626 - 1631

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被引用次数: 17

摘要

The growing importance of functionalized aziridines in numreous organic biomolecules led us to develop syntheses of novel actinomycin D (AMD) analogues substituted with an aziridine. Reaction of 7-hydroxyactinomycin D with 2-(iodomethyl) aziridine produced the desired 7-(2-aziridinylmethoxy) actinomycin analogue. In an attempt to develop an alternate route to this analogue, 7-(2-azido-3-iodopropoxy) actinomycin was subjected to reduction ...