Factor VIIa inhibitors: Improved pharmacokinetic parameters

A Kolesnikov, R Rai, WB Young, J Mordenti…

文献索引：Kolesnikov, Aleksandr; Rai, Roopa; Young, Wendy B.; Mordenti, Joyce; Liu, Liang; Torkelson, Steven; Shrader, William D.; Leahy, Ellen M.; Hu, Huiyong; Gjerstad, Erik; Janc, James; Katz, Bradley A.; Sprengeler, Paul A. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 8 p. 2243 - 2246

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被引用次数: 12

摘要

Efforts to improve the potency and pharmacokinetic properties of small molecule factor VIIa inhibitors are described. Small structural modifications to existing leads allow the modulation of half-life and clearance, potentially making these compounds suitable candidates for drug development.

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Factor VIIa inhibitors: gaining selectivity within the tryps...

[Shrader, William D.; Kolesnikov, Aleksandr; Burgess-Henry, Jana; Rai, Roopa; Hendrix, John; Hu, Huiyong; Torkelson, Steve; Ton, Tony; Young, Wendy B.; Katz, Bradley A.; Yu, Christine; Tang, Jie; Cabuslay, Ronnel; Sanford, Ellen; Janc, James W.; Sprengeler, Paul A. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1596 - 1600]

Small molecule inhibitors of plasma kallikrein

[Young, Wendy B.; Rai, Roopa; Shrader, William D.; Burgess-Henry, Jana; Hu, Huiyong; Elrod, Kyle C.; Sprengeler, Paul A.; Katz, Bradley A.; Sukbuntherng, Juthamas; Mordenti, Joyce Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 2034 - 2036]