Copper (I) phosphoramidite catalyzed asymmetric conjugate addition of dialkylzinc reagents of α, β-unsaturated nitroacetates; an enantioselective route to β-aryl- …
JPG Versleijen, AM van Leusen, BL Feringa
文献索引：Versleijen, Jos P. G.; Van Leusen, Albert M.; Feringa, Ben L. Tetrahedron Letters, 1999 , vol. 40, # 31 p. 5803 - 5806
The asymmetric copper (I) phosphoramidite catalyzed conjugate addition of dialkylzinc reagents to E, Z-mixtures of α, β-unsaturated nitroacetates provided the 1, 4-adducts in excellent yields but with low ee's. High enantioselectivities (ee's up to 92%) were obtained with structurally rigid 3-nitrocoumarins, leading to a new route to optically active β-aryl- nitroalkanes.
