One-pot synthesis of substituted δ1-pyrrolines through the michael addition of nitroalkanes to chalcones and subsequent reductive cyclization in aqueous media
Abstract A facile and efficient one-pot synthesis of substituted Δ 1-pyrrolines in aqueous media has been developed. Upon treatment with aqueous sodium hydroxide in N, N- dimethylformamide, a range of chalcones underwent room temperature Michael addition reactions with nitroalkanes. The resulting adducts were directly reduced in situ with Zn/HCl (aq) and subsequently underwent an intramolecular cyclization, affording the ...
