Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependant RNA polymerase: 2-aryl-3-heteroaryl-1, 3-thiazolidin-4-one derivatives

RK Rawal, SB Katti, N Kaushik-Basu, P Arora…

文献索引：Rawal, Ravindra K.; Katti; Kaushik-Basu, Neerja; Arora, Payal; Pan, Zhenhua Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6110 - 6114

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被引用次数: 31

摘要

Hepatitis C virus (HCV) NS5B RNA polymerase is crucial for replicating the HCV RNA genome and is an attractive target for developing anti-HCV drugs. A novel series of 2, 3- diaryl-1, 3-thiazolidin-4-one derivatives were evaluated for their ability to inhibit HCV NS5B. Of this series, compounds 4c, 5b, 5c and 6 emerged as more potent, displaying over 95% inhibition of NS5B RNA polymerase activity in vitro. The two most active compounds 4c ...