Tetrahedron letters

A two-step procedure for the preparation of mono-protected bis-N-heterocyclic alkyl ether systems

J Chao, M Israiel, J Zheng, C Aki

文献索引：Chao, Jianhua; Israiel, Mariam; Zheng, Junying; Aki, Cynthia Tetrahedron Letters, 2007 , vol. 48, # 5 p. 791 - 794

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被引用次数: 7

摘要

A two-step convenient sequence for the synthesis of previously inaccessible mono-Boc- protected bis-N-heterocyclic alkyl substituted ether derivatives 4 is described. Mitsunobu protocol was applied to the preparation of pyridinyl ether precursor 5. The reduction of the electron rich pyridinyl system 5 has been achieved catalytically using the combination of PtO2–H2SO4 or PtO2–pTsOH under a hydrogen atmosphere maintained by a gas balloon ...