Synlett

Convenient synthesis and isolation of 1-aminocyclopropane-1-carboxylic acid (ACC) and N-protected ACC derivatives

SP Allwein, EA Secord, A Martins, JV Mitten…

文献索引：Allwein, Shawn P.; Secord, Elizabeth A.; Martins, Andrew; Mitten, Jeffrey V.; Nelson, Todd D.; Kress, Michael H.; Dolling, Ulf H. Synlett, 2004 , # 14 p. 2489 - 2492

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被引用次数: 9

摘要

Abstract A convenient route to 1-aminocyclopropane-1-carboxylic acid (1, ACC) and N- protected derivatives was developed. This route utilizes a bisalkylation of an O-benzyl glycine derived imine followed by global deprotection via hydrogenation. Direct isolation of ACC from a non-aqueous stream or efficient conversion to N-protected derivatives in a single flask is described.