Investigation of the metabolism of the o-tolyl analog of fencarol
TB Chumburidze, VY Vorob'eva, EE Mikhlina…
文献索引：Chumburidze, T. B.; Vorob'eva, V. Ya.; Mikhlina, E. E.; Tupikina, S. M.; Kaminka, M. E.; et al. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 11 p. 796 - 800 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 11 p. 1300 - 1304
It is known that the inhibiting effect of OTC is removed by thiol compounds, for example, reducing glutathione, dihydrolipoate, 2, 3-dimercaptopropanol, anddihydrolipoamide [7]. Therefore it is most probable that the action of OTC is directed toward the SH groups of the enzyme systems enumerated above, and differences in the inhibition constants are explained by the different accessibility of these groups to the inhibitors.
