Synthesis and Properties of Substituted Isoxazolo [3', 4': 4, 5] thieno [2, 3-b] pyridines

…, A Kaigorodova, SI Firgang, GD Krapivin

文献索引：Vasilin; Kaigorodova; Firgang; Krapivin Chemistry of Heterocyclic Compounds, 2004 , vol. 40, # 3 p. 377 - 386

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被引用次数: 2

摘要

Abstract We synthesized derivatives of a novel heterocyclic system, isoxazolo [3', 4': 4, 5] thieno [2, 3-b] pyridine by sequential conversions in three steps: isomerization of 2-(2-R- ethylthio-2-oxo)-3-pyridyl cyanides obtained by alkylation from substituted 3-cyano-2 (1H)- pyridinethiones by α-halomethyl ketones in alkaline medium, to form 3-aminothieno [2, 3-b] pyridines; diazotization of the amino group followed by nucleophilic substitution of the ...