Tetrahedron Letters

A convenient transformation of α-alkylserines into α-halogenomethyl-α-alkylglycines

A Kudaj, A Olma

文献索引：Kudaj, Adam; Olma, Aleksandra Tetrahedron Letters, 2008 , vol. 49, # 45 p. 6445 - 6447

全文：HTML全文

被引用次数: 6

摘要

An efficient and facile synthesis of N-Boc-α-chloromethyl-and α-bromomethyl-α-alkylglycines is reported that involves cyclization of N-Boc-α-alkylserines to the corresponding β-lactones under Mitsunobu reaction conditions, followed by ring opening with anhydrous MgCl2 or MgBr2.