Synthesis and biological activity of 2-(4, 5-dihydroisoxazol-5-yl)-1, 3, 4-oxadiazoles

…, CL Yoo, TC Sparks, BA Lorsbach, MJ Kurth

文献索引：Milinkevich, Kristin A.; Yoo, Choong L.; Sparks, Thomas C.; Lorsbach, Beth A.; Kurth, Mark J. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 19 p. 5796 - 5798

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被引用次数: 23

摘要

Acid hydrazides were coupled with acrylic acid derivatives and cyclodehydration gave 1, 3, 4-oxadiazoles. Lastly, in-situ nitrile oxide formation from aryl oximes treated with sodium hypochlorite, and subsequent 1, 3-dipolar cycloaddition to the exomethylene moiety delivered 2-(4, 5-dihydroisoxazol-5-yl)-1, 3, 4-oxadiazoles. This library was evaluated in a high-throughput screen at Dow AgroSciences. Several compounds were active against ...