Synthesis of Substituted Quinazolines: Application to the Synthesis of Verubulin

…, Y Klimova, MB Anderson, JA Willardsen

文献索引：Lockman, Jeffrey W.; Klimova, Yevgeniya; Anderson, Mark B.; Willardsen, J. Adam Synthetic Communications, 2012 , vol. 42, # 12 p. 1715 - 1723

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被引用次数: 6

摘要

As part of our efforts to identify new cancer treatments, we examined the synthesis of 4-amino substituted quinazoline compounds such as verubulin (Azixa, MPC-6827, 1). [ 7 7. (a) Sirisoma , N. ; Kasibhatla , S. ; Pervin , A. ; Zhang , H. ; Jiang , S. ; Willardsen , JA ; Anderson , MB ; Baichwal , V. ; Mather , GG ; Jessing , K. ; Hussain , R. ; Hoang , K. ; Pleiman , CM ; Tseng , B. ; Drewe , J. ; Cai , SX Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine ( ...