Synthesis and anti-CVB 3 evaluation of substituted 5-nitro-2-phenoxybenzonitriles

…, G Zimmerhofer, S Huber, S Ladurner, J Neyts

文献索引：Puerstinger, Gerhard; De Palma, Armando M.; Zimmerhofer, Guenther; Huber, Simone; Ladurner, Sophie; Neyts, Johan Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 18 p. 5123 - 5125

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被引用次数: 7

摘要

The synthesis and SAR of a series of 60 substituted 2-phenoxy-5-nitrobenzonitriles (analogues of MDL-860) as inhibitors of enterovirus replication (in particular of coxsackievirus B3 (CVB 3)) are reported. Several of the analogues inhibited CVB 3 and other enteroviruses at low-micromolar concentrations.