Journal of medicinal chemistry

Synthesis and structure-activity relationship studies for hydantoins and analogues as voltage-gated sodium channel ligands

C Zha, GB Brown, WJ Brouillette

文献索引：Zha, Congxiang; Brown, George B.; Brouillette, Wayne J. Journal of Medicinal Chemistry, 2004 , vol. 47, # 26 p. 6519 - 6528

全文：HTML全文

被引用次数: 43

摘要

We previously developed a preliminary 3-D QSAR model for the binding of 14 hydantoins to the neuronal voltage-gated sodium channel; this model was successful in designing an effective non-hydantoin ligand. To further understand structural features that result in optimum binding, here we synthesized a variety of compound classes and evaluated their binding affinities to the neuronal voltage-gated sodium channel using the [3H]- ...