Syntheses and in vitro evaluation of 4-(2-aminoethyl)-2 (3H)-indolones and related compounds as peripheral prejunctional dopamine receptor agonists

RM DeMarinis, RF Hall, RG Franz…

文献索引：DeMarinis, Robert M.; Gallagher, Gregory; Hall, Ralph F.; Franz, Robert G.; Webster, Charles; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 939 - 947

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被引用次数: 32

摘要

13 40: X= OS02CH3 4 1: X= N (n-Pr) p ear artery (REA) to electrical field stimulation, and this effect is competitively antagonized by the dopaminergic receptor antagonist (S)- sulpiride. Our data show that the pharmacological effects of 26 and 28 are mediated primarily through activation of peripheral prejunctional D2 receptors, since neither 26 nor 28 is able to stimulate or block the dopamine-sensitive adenylate cyclase of rat caudate at ...