Journal of medicinal chemistry

Double-head haptens. Synthesis of and experimentally induced contact sensitivity to substances containing two unrelated haptens, pyrocatechol and. alpha.- …

B Marchand, C Benezra

文献索引：Marchand, Bernard; Benezra, Claude Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 650 - 653

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被引用次数: 18

摘要

Many pharmaceutical preparations, eg, perfumes and cosmetics, contain more than one contact sensitizer; this can result in simultaneous sensitization, a not uncommon phenomenon. This is known as “cosensitization”.l The clinical result (sensitivity to more than one allergen or hapten) is the expression of an antigenic competition at the molecular (hapten plus carrier) and cellular (on im- munologically competent cells) levels. Because the timing of sensitization ...