Modifications of primaquine as antimalarials. 4. 5-Alkoxy derivatives of primaquine

…, K Tanabe, AJ Saggiomo, EA Nodiff

文献索引：Chen, Eugene H.; Tanabe, Keiichi; Saggiomo, Andrew J.; Nodiff, Edward A. Journal of Medicinal Chemistry, 1987 , vol. 30, # 7 p. 1193 - 1199

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被引用次数: 14

摘要

Thirty-two 5-alkoxyprimaquines have been synthesized and evaluated as blood schizonticides (Plasmodium berghei, mouse) and tissue schizonticides (Plasmodium cynomolgi, monkey). Several of these compounds were extremely active in both screens. Such a broad spectrum of antimalarial efficacy offers the possibility of a single drug that could cure the various relapsing and nonrelapsing malarias.