Studies on Mimicry of Naturally Occurring Annonaceous Acetogenins: Non??THF Analogues Leading to Remarkable Selective Cytotoxicity against Human Tumor Cells

BB Zeng, Y Wu, S Jiang, Q Yu, ZJ Yao…

文献索引：Zeng, Bu-Bing; Wu, Yikang; Jiang, Sheng; Yu, Qian; Yao, Zhu-Jun; Liu, Zhong-Hai; Li, Hong-Yan; Li, Yan; Chen, Xiao-Guang; Wu, Yu-Lin Chemistry - A European Journal, 2003 , vol. 9, # 1 p. 282 - 290

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被引用次数: 40

摘要

Abstract A class of structurally simplified analogues of the naturally occurring annonaceous acetogenins were developed, amongst which some non-THF analogues showed remarkable cytotoxicities against tumor cell lines, as well as good selectivity between human tumor cells and normal cells. The synthetic routes were significantly shortened because of the removal of the chiral centers bearing the THF rings on the natural templates. This ...