Chemistry Letters

One-pot cyclization of a peptide by the use of (5-nitropyridyl) diphenyl phosphinate: the synthesis of cyclic decapeptide gramicidin S

T Mukaiyama, K Kamekawa, Y Watanabe

文献索引：Mukaiyama, Teruaki; Kamekawa, Kenichi; Watanabe, Yutaka Chemistry Letters, 1981 , p. 1367 - 1370

全文：HTML全文

被引用次数: 13

摘要

One-pot synthesis of gramicidin S, cyclic decapeptide, was successfully achieved by treatment of the corresponding linear decapeptide with (5-nitropyridyl) diphenyl phosphinate, a new condensing reagent, in pyridine. Similarly, the phosphinic ester can be successfully employed in the Young test as well as syntheses of dipeptides.