Structural variations of 1-(4-(phenoxymethyl) benzyl) piperidines as nonimidazole histamine H 3 receptor antagonists

…, HH Pertz, JM Arrang, CR Ganellin, JC Schwartz…

文献索引：Miko, Tibor; Ligneau, Xavier; Pertz, Heinz H.; Arrang, Jean-Michel; Ganellin, C. Robin; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 10 p. 2727 - 2736

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被引用次数: 14

摘要

Recent bioisoteric replacements in histamine H3 receptor ligands with an exchange of the imidazole moiety by a piperidino group as well as of the trimethylene chain in 4-((3- phenoxy) propyl)-lH-imidazole derivatives (proxifan class) by an α, α′-xylendiyl linker represents the starting point in the development of 1-(4-(phenoxymethyl) benzyl) piperidines as a new class of nonimidazole histamine H3 receptor antagonists. According to different ...