The structure–activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs

YG Suh, SN Kim, DY Shin, SS Hyun, DS Lee…

文献索引：Suh, Young-Ger; Kim, Sun Nam; Shin, Dong-Yun; Hyun, Soon-Sil; Lee, Do-Sang; Min, Kyung-Hoon; Han, Sae Mi; Li, Funan; Choi, Eung-Chil; Choi, Seong-Hak Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 142 - 145

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被引用次数: 15

摘要

For the systematic SAR study on mansonone F, a series of C6 and C9 analogs of mansonone F have been synthesized and their anti-MRSA activities were evaluated. Most of the analogs exhibited good or excellent anti-MRSA activities. In particular, the 6-n- butylmansonone F showed fourfold higher antibacterial activities compared to that of vancomycin.