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Synthesis of pinacol esters of 1??alkyl??1H??pyrazol??5??yl??and 1??alkyl??1H??pyrazol??4??ylboronic acids

AV Ivachtchenko, DV Kravchenko…

文献索引:Ivachtchenko, Alexandre V.; Kravchenko, Dmitry V.; Zheludeva, Valentina I.; Pershin, Dmitry G. Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 6 p. 931 - 939

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被引用次数: 25

摘要

Abstract Starting from 1H-pyrazol, a wide number of 1-alkyl-1H-pyrazol-4-yl and 1-alkyl-1H- pyrazol-5-ylboronic acids and their pinacol esters were synthesized and characterized. The key step in the described methodology is the regioselective lithiation of the pyrazole ring. The synthesized pinacolates are stable under prolonged storage and can be used as convenient reagents in organic synthesis.

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