Direct cupration of fluoroform

…, MA Novikov, E Martin, J Benet-Buchholz…

文献索引：Zanardi, Alessandro; Novikov, Maxim A.; Martin, Eddy; Benet-Buchholz, Jordi; Grushin, Vladimir V. Journal of the American Chemical Society, 2011 , vol. 133, # 51 p. 20901 - 20913

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被引用次数: 185

摘要

We have found the first reaction of direct cupration of fluoroform, the most attractive CF3 source for the introduction of the trifluoromethyl group into organic molecules. Treatment of CuX (X= Cl, Br, I) with 2 equiv of MOR (M= K, Na) in DMF or NMP produces novel alkoxycuprates that readily react with CF3H at room temperature and atmospheric pressure to give CuCF3 derivatives. The CuCl and t-BuOK (1: 2) combination provides best results, ...