Structure− Activity Relationships of Adenine and Deazaadenine Derivatives as Ligands for Adenine Receptors, a New Purinergic Receptor Family

…, C Lambertucci, E Alksnis, S Gorzalka…

文献索引：Borrmann, Thomas; Abdelrahman, Aliaa; Volpini, Rosaria; Lambertucci, Catia; Alksnis, Edgars; Gorzalka, Simone; Knospe, Melanie; Schiedel, Anke C.; Cristalli, Gloria; Mueller, Christa E. Journal of Medicinal Chemistry, 2009 , vol. 52, # 19 p. 5974 - 5989

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被引用次数: 33

摘要

Adenine derivatives bearing substituents in the 2-, N 6-, 7-, 8-, and/or 9-position and a series of deazapurines were synthesized and investigated in [3H] adenine binding studies at the adenine receptor in rat brain cortical membrane preparations (rAde1R). Steep structure− activity relationships were observed. Substitution in the 8-position (amino, dimethylamino, piperidinyl, piperazinyl) or in the 9-position (2-morpholinoethyl) with basic residues or ...