前往化源商城

举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Analogs of 1, 5-bis (4-amidinophenoxy) pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia

…, JD Geratz, KA Ohemeng, M Cory, JE Hall

文献索引：Tidwell; Jones; Geratz; Ohemeng; Cory; Hall Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1252 - 1257

全文：HTML全文

被引用次数: 141

摘要

A series of 33 analogues of the anti-Pneumocystis carinii drug 1, 5-bis (4-amidinophenoxy) pentane (pentamidine) was synthesized for screening against a rat model of P. carinii pneumonia (PCP). Twenty-five of the compounds showed efficacy against PCP when compared to a saline-treated control group. Two compounds, 1, 4-bis (4-amidinophen0xy) butane (butamidine, 6) and 1, 3-bis (4-amidino-2-methoxyphenoxy) propane (DAMP, 16), ...

1,6-二溴己烷结构式

1,6-二溴己烷

4-羟基苯甲腈结构式

4-羟基苯甲腈

~%

4,4'-(己烷-1,6-二基双(氧基))二苯甲腈结构式

4,4'-(己烷-1,6-二基...

查看详情

对氟苯腈结构式

~%

4-[3-[(4-carbamimidoylphenyl)amino]propylamino]benzenecarboximidamide结构式

4-[3-[(4-carbam...

查看详情

未登录结构式

~%

4-[3-[(4-carbamimidoylphenyl)amino]propylamino]benzenecarboximidamide结构式

4-[3-[(4-carbam...

查看详情

1,5-二溴戊烷结构式

1,5-二溴戊烷

~%

2-[4-[5-[4-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]pentoxy]phenyl]-4,5-dihydro-1H-imidazole结构式

2-[4-[5-[4-(4,5...

查看详情

4,4'-(戊烷-1,5-二酰基双(氧))二苯腈结构式

4,4'-(戊烷-1,5-二酰...

~%

2-[4-[5-[4-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]pentoxy]phenyl]-4,5-dihydro-1H-imidazole结构式

2-[4-[5-[4-(4,5...

查看详情

4-羟基苯甲腈结构式

4-羟基苯甲腈

~%

2-[4-[5-[4-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]pentoxy]phenyl]-4,5-dihydro-1H-imidazole结构式

2-[4-[5-[4-(4,5...

查看详情

1,6-二溴己烷结构式

1,6-二溴己烷

~%

己脒定结构式

查看详情

4,4'-(己烷-1,6-二基双(氧基))二苯甲腈结构式

4,4'-(己烷-1,6-二基...

~%

己脒定结构式

查看详情

4-羟基苯甲腈结构式

4-羟基苯甲腈

~%

己脒定结构式

查看详情

4-羟基-3-甲氧基苯甲腈结构式

4-羟基-3-甲氧基苯甲腈

~%

4-[4-(4-carbamimidoyl-2-methoxyphenoxy)butoxy]-3-methoxybenzenecarboximidamide结构式

4-[4-(4-carbami...

查看详情

3,3'-dimethoxy-4,4'-butanediyldioxy-di-benzonitrile结构式

3,3'-dimethoxy-...

~%

4-[4-(4-carbamimidoyl-2-methoxyphenoxy)butoxy]-3-methoxybenzenecarboximidamide结构式

4-[4-(4-carbami...

查看详情

对氯苯腈结构式

~88%

4-氯-3-硝基苯腈结构式

4-氯-3-硝基苯腈

查看详情

1,2-Bis(4-cyanophenoxy)ethane结构式

1,2-Bis(4-cyano...

~%

4-[2-(4-carbamimidoylphenoxy)ethoxy]benzenecarboximidamide结构式

4-[2-(4-carbami...

查看详情

4-羟基苯甲腈结构式

4-羟基苯甲腈

~%

4-[2-(4-carbamimidoylphenoxy)ethoxy]benzenecarboximidamide结构式

4-[2-(4-carbami...

查看详情

1,5-二溴戊烷结构式

1,5-二溴戊烷

~%

3-[5-(3-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide结构式

3-[5-(3-carbami...

查看详情

3-羟基苯腈结构式

~%

3-[5-(3-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide结构式

3-[5-(3-carbami...

查看详情

3-[5-(3-cyanophenoxy)pentoxy]benzonitrile结构式

3-[5-(3-cyanoph...

~%

3-[5-(3-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide结构式

3-[5-(3-carbami...

查看详情

3-羟基苯腈结构式

~%

3-[4-(3-carbamimidoylphenoxy)butoxy]benzenecarboximidamide结构式

3-[4-(3-carbami...

查看详情

3-[4-(3-cyanophenoxy)butoxy]benzonitrile结构式

3-[4-(3-cyanoph...

~%

3-[4-(3-carbamimidoylphenoxy)butoxy]benzenecarboximidamide结构式

3-[4-(3-carbami...

查看详情

1,4-二溴丁烷结构式

1,4-二溴丁烷

3-羟基苯腈结构式

~%

3-[4-(3-cyanophenoxy)butoxy]benzonitrile结构式

3-[4-(3-cyanoph...

查看详情

1,5-二溴戊烷结构式

1,5-二溴戊烷

3-羟基苯腈结构式

~%

3-[5-(3-cyanophenoxy)pentoxy]benzonitrile结构式

3-[5-(3-cyanoph...

查看详情

4,4'-(己烷-1,6-二基双(氧基))二苯甲腈结构式

4,4'-(己烷-1,6-二基...

~85%

4-[6-(4-cyano-2-nitrophenoxy)hexoxy]-3-nitrobenzonitrile结构式

4-[6-(4-cyano-2...

查看详情

1,6-二溴己烷结构式

1,6-二溴己烷

~%

4-[6-(4-cyano-2-nitrophenoxy)hexoxy]-3-nitrobenzonitrile结构式

4-[6-(4-cyano-2...

查看详情

4-羟基苯甲腈结构式

4-羟基苯甲腈

~%

4-[6-(4-cyano-2-nitrophenoxy)hexoxy]-3-nitrobenzonitrile结构式

4-[6-(4-cyano-2...

查看详情

3,3'-dichloro-4,4'-pentanediyldioxy-di-benzonitrile结构式

3,3'-dichloro-4...

~%

4-[5-(4-carbamimidoyl-2-chlorophenoxy)pentoxy]-3-chlorobenzenecarboximidamide结构式

4-[5-(4-carbami...

查看详情

3-氯-4-羟基苯甲腈结构式

3-氯-4-羟基苯甲腈

~%

4-[5-(4-carbamimidoyl-2-chlorophenoxy)pentoxy]-3-chlorobenzenecarboximidamide结构式

4-[5-(4-carbami...

查看详情

对氯苯腈结构式

~%

4-[3-[(4-carbamimidoyl-2-nitro-phenyl)amino]propylamino]-3-nitro-benze necarboximidamide结构式

4-[3-[(4-carbam...

查看详情

4-氯-3-硝基苯腈结构式

4-氯-3-硝基苯腈

~%

4-[3-[(4-carbamimidoyl-2-nitro-phenyl)amino]propylamino]-3-nitro-benze necarboximidamide结构式

4-[3-[(4-carbam...

查看详情

3-羟基苯腈结构式

~%

3-[3-(3-carbamimidoylphenoxy)propoxy]benzenecarboximidamide结构式

3-[3-(3-carbami...

查看详情

1,6-二溴己烷结构式

1,6-二溴己烷

~%

3-[6-(3-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide结构式

3-[6-(3-carbami...

查看详情

3-羟基苯腈结构式

~%

3-[6-(3-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide结构式

3-[6-(3-carbami...

查看详情

3-[6-(3-cyanophenoxy)hexoxy]benzonitrile结构式

3-[6-(3-cyanoph...

~%

3-[6-(3-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide结构式

3-[6-(3-carbami...

查看详情

2,2'-dimethoxy-4,4'-dicyano-α,ω-diphenoxypentane结构式

2,2'-dimethoxy-...

~%

4-[5-(4-carbamimidoyl-2-methoxyphenoxy)pentoxy]-3-methoxybenzenecarboximidamide结构式

4-[5-(4-carbami...

查看详情

4-羟基-3-甲氧基苯甲腈结构式

4-羟基-3-甲氧基苯甲腈

~%

4-[5-(4-carbamimidoyl-2-methoxyphenoxy)pentoxy]-3-methoxybenzenecarboximidamide结构式

4-[5-(4-carbami...

查看详情

对氯苯腈结构式

~%

3-amino-4-[2-(2-amino-4-carbamimidoylanilino)ethylamino]benzenecarboximidamide结构式

3-amino-4-[2-(2...

查看详情

4-氯-3-硝基苯腈结构式

4-氯-3-硝基苯腈

~%

3-amino-4-[2-(2-amino-4-carbamimidoylanilino)ethylamino]benzenecarboximidamide结构式

3-amino-4-[2-(2...

查看详情