Synthesis and physicochemical characterization of novel phenotypic probes targeting the nuclear factor-kappa B signaling pathway

PM Hershberger, S Peddibhotla…

文献索引：Hershberger, Paul M.; Peddibhotla, Satyamaheshwar; Sessions, E. Hampton; Divlianska, Daniela B.; Correa, Ricardo G.; Pinkerton, Anthony B.; Reed, John C.; Roth, Gregory P. Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 900 - 907

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被引用次数: 1

摘要

Abstract Activation of nuclear factor-kappa B (NF-κB) and related upstream signal transduction pathways have long been associated with the pathogenesis of a variety of inflammatory diseases and has recently been implicated in the onset of cancer. This report provides a synthetic and compound-based property summary of five pathway-related small- molecule chemical probes identified and optimized within the National Institutes of Health- ...