Tetrahedron

Syntheses of sphingomyelin methylene, aza, and sulfur analogues by the versatile olefin cross-metathesis method

T Yamamoto, H Hasegawa, S Ishii, S Kaji, T Masuyama…

文献索引：Yamamoto, Tetsuya; Hasegawa, Hiroko; Ishii, Sekimi; Kaji, Satoshi; Masuyama, Tatsuro; Harada, Syuji; Katsumura, Shigeo Tetrahedron, 2008 , vol. 64, # 51 p. 11647 - 11660

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被引用次数: 11

摘要

The syntheses of optically homogeneous sphingomyelin analogues, which possess CH2, NH, and S instead of the phosphate oxygen connecting the phosphocholine head group to the sphingosine backbone, were successfully achieved by employing the olefin cross- metathesis protocol between 1-pentadecene and the amino alcohol parts possessing the suitable building block or functional group for construction of the phosphocholine moiety. ...