Enantioselective synthesis of derivatives and structure–activity relationship study in the development of NA255 as a novel host-targeting anti-HCV agent

…, T Hayase, S Komiyama, F Watanabe, H Fukuda…

文献索引：Kawasaki, Ken-Ichi; Masubuchi, Miyako; Hayase, Tadakatsu; Komiyama, Susumu; Watanabe, Fumio; Fukuda, Hiroshi; Murata, Takeshi; Matsubara, Yasuaki; Koyama, Kouhei; Shindoh, Hidetoshi; Sakamoto, Hiroshi; Okamato, Kohichi; Ohta, Atsunori; Katsume, Asao; Aoki, Masahiro; Aoki, Yuko; Shimma, Nobuo; Sudoh, Masayuki; Tsukuda, Takuo Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 336 - 339

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被引用次数: 1

摘要

Hepatitis C virus (HCV) infection represents a serious health-care problem. Previously we reported the identification of NA255 from our natural products library using a HCV sub- genomic replicon cell culture system. Herein, we report how the absolute stereochemistry of NA255 was determined and an enantioselective synthetic method for NA255 derivatives was developed. The structure–activity relationship of the NA255 derivatives and rat ...