Design, synthesis and biological evaluation of hydroxy-or methoxy-substituted phenylmethylenethiosemicarbazones as tyrosinase inhibitors

…, RH Cao, ZY Chen, L Yu, L Ma, HC Song

文献索引：Yi, Wei; Cao, Ri-Hui; Chen, Zhi-Yong; Yu, Liang; Ma, Lin; Song, Hua-Can Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 11 p. 1273 - 1277

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被引用次数: 24

摘要

A series of hydroxy-or methoxy-substituted phenylmethylenethiosemicarbazones were designed, synthesized and evaluated as mushroom tyrosinase inhibitors. The results demonstrated that most of target compounds had remarkable inhibitory activities on mushroom tyrosinase. Interestingly, compound 2h was found to be the most potent tyrosinase inhibitor with IC 50 value of 0.18 μM. The possible interaction mode between ...