Synlett

DBU-Promoted Facile, Chemoselective Cleavage of Acetylenic TMS Group

CE Yeom, MJ Kim, W Choi, BM Kim

文献索引：Yeom, Chang-Eun; Mi, Jeong Kim; Choi, Whail; Kim, B. Moon Synlett, 2008 , # 4 p. 565 - 568

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被引用次数: 10

摘要

Abstract Acetylenic trimethylsilyl (TMS) groups were efficiently removed using 1, 8- diazabicyclo [5.4. 0] undec-7-ene (DBU). With either 1.0 or even 0.1 equivalents of DBU, smooth desilylation of various terminal acetylenic TMS groups was accomplished selectively in the presence of alkyl silyl ethers and other base-labile groups. Furthermore, more sterically hindered terminal acetylenic silyl groups such as TBDMS and TIPS remained ...