A comparison of the inhibitory action of 5-(substituted-benzyl)-2, 4-diaminopyrimidines on dihydrofolate reductase from chicken liver with that from bovine liver
RL Li, C Hansch, BT Kaufman
文献索引：Li, Ren-li; Hansch, Corwin; Kaufman, Bernard T. Journal of Medicinal Chemistry, 1982 , vol. 25, # 4 p. 435 - 440
Results The log (l/Kiapp) values for the action of variations of I on the two forms of DHFR are given in Table I for assay at pH 7.2. In our earlier report5 on the action of I on the bovine reductase, a number of the measurements were made at pH 6.25. The activity of these has now been determined at pH 7.2; in addition, we have also synthesized eight new congeners.
